Born in San Juan in 1967, Enoc Perez first took painting lessons at the age of eight. As the son of an art critic, he spent family vacations traveling to museums in different countries and learning about the history of art. In 1986, Perez moved to New York to study painting at the Pratt Institute before earning his master's degree at Hunter College.

Perez is best known for his paintings of modernist buildings that nostalgically capture the utopian ambitions and optimism that inspired their construction.

For twenty years, Perez worked in a technique related to the printmaking process. Inspired by the influence of Andy Warhol and his silkscreens on the New York art scene, Perez developed his own innovative method that mimicked the process of color printing. Working from both reproductions and his own photographs, Perez made separate preparatory drawings for each color he desired in his finished painting. He applied oil paint to the back of each these sheets and pressed them to the canvas to transfer the color. In 2010, Perez decided to begin working with brushes again.